Research workbench
Vibrio vulnificus stressosome
Analyse Vibrio vulnificus stressosome in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7O0I
- Type
- protein
- Length
- 7,356 residues
- Chains
- 60
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rsbs, negative regulator of sigma-B; Anti-anti-sigma factor
- UniProt
- A0A2S3QZH9, A0A1W6M9Q5
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 48% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| a, b, A, D, O, P, e, f, g, t, u, v | Rsbs, negative regulator of sigma-B | protein | 113 | 43% helix, 12% strand | A0A2S3QZH9 |
| B, C, E, F, G, H, I, J, K, L, M, N, Q, R, S, T, U, V, W, X, Y, Z, c, d, h, i, j, k, l, m, n, o, p, q, r, s, w, x, y, z, 1, 2, 4, 5, 6, 7, 8, 9 | Anti-anti-sigma factor | protein | 125 | 53% helix, 6% strand | A0A1W6M9Q5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 995 | 0.82 | 0.83 | 139 | empty |
| 2 | 1026 | 0.82 | 0.83 | 152 | empty |
| 3 | 1100 | 0.82 | 0.83 | 154 | empty |
| 4 | 1027 | 0.82 | 0.83 | 137 | empty |
| 5 | 900 | 0.81 | 0.83 | 128 | empty |
Interfaces
90 interfaces between chains.
- m–2 · 275 Ų buried · 0 hydrogen bonds · protein-protein
- H–V · 272 Ų buried · 0 hydrogen bonds · protein-protein
- U–1 · 248 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 244 Ų buried · 0 hydrogen bonds · protein-protein
- G–l · 244 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7O0I · Vibrio vulnificus stressosome · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2S3QZH9
- Every structure of UniProt A0A1W6M9Q5
- Elsewhere: RCSB PDB 7O0I · PDBe 7O0I · UniProt A0A2S3QZH9 · UniProt A0A1W6M9Q5
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