Research workbench
RAS1 guanine nucleotide exchange factor CDC25 (rem and catalytic domains)
Analyse RAS1 guanine nucleotide exchange factor CDC25 (rem and catalytic domains) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NZZ
- Type
- protein
- Length
- 840 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division control protein 25
- UniProt
- P43069
- Pockets
- 8 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division control protein 25 | protein | 421 | 66% helix, 3% strand | P43069 |
| B | Cell division control protein 25 | protein | 419 | 64% helix, 3% strand | P43069 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 847 | 0.68 | 0.75 | 90 | empty |
| 2 | 127 | 0.40 | 0.74 | 18 | empty |
| 3 | 94 | 0.37 | 0.75 | 20 | empty |
| 4 | 106 | 0.35 | 0.73 | 18 | empty |
| 5 | 76 | 0.34 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 592 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7NZZ · Ras1 guanine nucleotide exchange factor Cdc25 (REM and catalytic domains) · the same entry in another collection · chain A against A, TM-score 1.00
- P43069 · AlphaFold monomer V2.0 prediction for cell division control protein 25 (P43069) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43069
- Elsewhere: RCSB PDB 7NZZ · PDBe 7NZZ · UniProt P43069
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