Research workbench
Rhinovirus 14 icam-1 virion-like particle at pH 6.2
Analyse Rhinovirus 14 icam-1 virion-like particle at pH 6.2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NUN
- Type
- protein + RNA
- Length
- 813 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Octanucleotide; Genome polyprotein
- EC
- 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- P03303
- Pockets
- 11 · best druggability 0.75
Structure
electron microscopy · 5 distinct chains · 11% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Octanucleotide | rna | 8 | — | — |
| 1 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 273 | 10% helix, 31% strand | P03303 |
| 2 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 256 | 13% helix, 39% strand | P03303 |
| 3 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 236 | 9% helix, 32% strand | P03303 |
| 4 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 40 | 18% helix, 3% strand | P03303 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.75 | 0.97 | 23 | empty |
| 2 | 83 | 0.58 | 0.87 | 20 | empty |
| 3 | 146 | 0.45 | 0.76 | 35 | empty |
| 4 | 94 | 0.43 | 0.79 | 22 | empty |
| 5 | 96 | 0.40 | 0.77 | 18 | empty |
Interfaces
8 interfaces between chains.
- 1–3 · 4140 Ų buried · 61 hydrogen bonds · protein-protein
- 1–2 · 2108 Ų buried · 35 hydrogen bonds · protein-protein
- 2–3 · 1673 Ų buried · 15 hydrogen bonds · protein-protein
- 1–4 · 948 Ų buried · 9 hydrogen bonds · protein-protein
- 3–4 · 875 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7NUN · Rhinovirus 14 ICAM-1 virion-like particle at pH 6.2 · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03303
- Elsewhere: RCSB PDB 7NUN · PDBe 7NUN · UniProt P03303
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