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Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

Analyse Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PLQ
Type: protein
Length: 258 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proliferating cell nuclear antigen (PCNA)
UniProt: P15873
Ligands: HG
Pockets: 3 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proliferating cell nuclear antigen (PCNA)	protein	258	19% helix, 44% strand	P15873

Ligands and binding sites

HG · Mercury (II) ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.44	0.79	16	empty
2	59	0.32	0.76	15	empty
3	51	0.25	0.73	12	empty

Compared structures

1PLQ · Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA · the same entry in another collection · chain A against A, TM-score 1.00
P15873 · AlphaFold monomer V2.0 prediction for proliferating cell nuclear antigen (P15873) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15873
Elsewhere: RCSB PDB 1PLQ · PDBe 1PLQ · UniProt P15873

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