Research workbench

Human SDH/NAD+ complex

Analyse Human SDH/NAD+ complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PL8
Type: protein
Length: 1,424 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human sorbitol dehydrogenase
EC: 1.1.1.14
UniProt: Q00796
Ligands: NAD, ZN
Pockets: 16 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Human sorbitol dehydrogenase (EC 1.1.1.14)	protein	356	31% helix, 27% strand	Q00796

Ligands and binding sites

NAD · Nicotinamide-adenine-dinucleotide · ligand · 4 copies · chains A, B, C, D
ZN · Zinc ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	613	0.71	0.79	71	NAD
2	604	0.71	0.79	62	NAD
3	584	0.69	0.78	60	NAD
4	538	0.69	0.79	49	NAD
5	359	0.62	0.78	53	empty

Interfaces

5 interfaces between chains.

A–B · 649 Å² buried · 2 hydrogen bonds · protein-protein
C–D · 641 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 462 Å² buried · 6 hydrogen bonds · protein-protein
B–D · 24 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 23 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1PL8 · human SDH/NAD+ complex · the same entry in another collection · chain D against D, TM-score 1.00
Q00796 · AlphaFold monomer V2.0 prediction for sorbitol dehydrogenase (Q00796) · a predicted model of the same protein · chain C against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00796
Elsewhere: RCSB PDB 1PL8 · PDBe 1PL8 · UniProt Q00796

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