Research workbench
Putative glycerol kinase-like proteins anchored on an array of voltage dependent anion channels in the outer mitochondrial membrane of pig sperm mitochondria
Analyse Putative glycerol kinase-like proteins anchored on an array of voltage… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NIE
- Type
- protein
- Length
- 5,476 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycerol kinase; Voltage-dependent anion-selective channel protein 2
- EC
- 2.7.1.30
- UniProt
- A0A287BD08, F1S2F6
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 2 distinct chains · 27% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, O, P | Glycerol kinase (EC 2.7.1.30) | protein | 487 | 41% helix, 23% strand | A0A287BD08 |
| C, D, E, F, G, H, I, J, K, L, M, N | Voltage-dependent anion-selective channel protein 2 | protein | 294 | 4% helix, 65% strand | F1S2F6 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 880 | 0.75 | 0.78 | 76 | empty |
| 2 | 754 | 0.74 | 0.79 | 78 | empty |
| 3 | 826 | 0.74 | 0.78 | 91 | empty |
| 4 | 758 | 0.72 | 0.78 | 68 | empty |
| 5 | 667 | 0.72 | 0.79 | 67 | empty |
Interfaces
18 interfaces between chains.
- O–P · 1713 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1702 Ų buried · 19 hydrogen bonds · protein-protein
- C–F · 760 Ų buried · 37 hydrogen bonds · protein-protein
- L–M · 660 Ų buried · 22 hydrogen bonds · protein-protein
- K–L · 648 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7NIE · putative glycerol kinase-like proteins anchored on an array of voltage dependent anion… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A287BD08
- Every structure of UniProt F1S2F6
- Elsewhere: RCSB PDB 7NIE · PDBe 7NIE · UniProt A0A287BD08 · UniProt F1S2F6
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