Research workbench
Wzc-K540M-4YE C1
Analyse Wzc-K540M-4YE C1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NIB
- Type
- protein
- Length
- 4,543 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase
- EC
- 2.7.10.2
- UniProt
- A0A778WL64
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 5 distinct chains · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Tyrosine-protein kinase (EC 2.7.10.2) | protein | 651 | 48% helix, 17% strand | A0A778WL64 |
| B, G | Tyrosine-protein kinase (EC 2.7.10.2) | protein | 552 | 41% helix, 20% strand | A0A778WL64 |
| C, H | Tyrosine-protein kinase (EC 2.7.10.2) | protein | 553 | 41% helix, 21% strand | A0A778WL64 |
| E | Tyrosine-protein kinase (EC 2.7.10.2) | protein | 518 | 38% helix, 21% strand | A0A778WL64 |
| F | Tyrosine-protein kinase (EC 2.7.10.2) | protein | 513 | 36% helix, 21% strand | A0A778WL64 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 954 | 0.83 | 0.84 | 99 | empty |
| 2 | 605 | 0.79 | 0.84 | 66 | empty |
| 3 | 606 | 0.72 | 0.80 | 51 | empty |
| 4 | 586 | 0.71 | 0.80 | 50 | empty |
| 5 | 649 | 0.71 | 0.79 | 54 | empty |
Interfaces
8 interfaces between chains.
- B–C · 2109 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 1997 Ų buried · 19 hydrogen bonds · protein-protein
- A–H · 1711 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 1657 Ų buried · 25 hydrogen bonds · protein-protein
- F–G · 1569 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 7NIB · Wzc-K540M-4YE C1 · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A778WL64
- Elsewhere: RCSB PDB 7NIB · PDBe 7NIB · UniProt A0A778WL64
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