Research workbench
1918 H1N1 viral influenza polymerase heterotrimer - replicase (class 3)
Analyse 1918 H1N1 viral influenza polymerase heterotrimer - replicase (class 3) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NI0
- Type
- protein + RNA
- Length
- 1,817 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase acidic protein; RNA-directed RNA polymerase catalytic subunit; Polymerase…
- EC
- 3.1.-.-, 2.7.7.48
- UniProt
- Q3HM39, Q3HM40, Q3HM41
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 5 distinct chains · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase acidic protein (EC 3.1.-.-) | protein | 517 | 41% helix, 16% strand | Q3HM39 |
| B | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 738 | 46% helix, 14% strand | Q3HM40 |
| C | Polymerase basic protein 2,IMMUNOGLOBULIN G-binding protein a | protein | 539 | 35% helix, 19% strand | Q3HM41 |
| E | RNA (5'-R(P*GP*GP*CP*CP*UP*GP*CP*U)-3') | rna | 8 | — | — |
| D | RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)- 3') | rna | 15 | — | — |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 717 | 0.84 | 0.88 | 85 | empty |
| 2 | 939 | 0.82 | 0.84 | 94 | empty |
| 3 | 723 | 0.82 | 0.86 | 69 | empty |
| 4 | 488 | 0.79 | 0.86 | 46 | empty |
| 5 | 249 | 0.76 | 0.90 | 40 | empty |
Interfaces
9 interfaces between chains.
- A–B · 8151 Ų buried · 108 hydrogen bonds · protein-protein
- B–C · 7266 Ų buried · 75 hydrogen bonds · protein-protein
- A–D · 1354 Ų buried · 28 hydrogen bonds · protein-nucleic
- A–C · 1018 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 669 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 7NI0 · 1918 H1N1 Viral influenza polymerase heterotrimer - Replicase (class 3) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3HM39
- Every structure of UniProt Q3HM40
- Every structure of UniProt Q3HM41
- Elsewhere: RCSB PDB 7NI0 · PDBe 7NI0 · UniProt Q3HM39 · UniProt Q3HM40 · UniProt Q3HM41
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.