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Crystal structure of L-TRP/INDOLEAMINE 2,3-dioxygenagse 1 (HIDO1) complex with the jk-loop refined in the closed conformation

Analyse Crystal structure of L-TRP/INDOLEAMINE 2,3-dioxygenagse 1 (HIDO1) complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7NGE
Type: protein
Length: 1,505 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P14902
Ligands: HEM, NA, PO4, CL

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	388	—	P14902
B	—	protein	370	—	P14902
C	—	protein	378	—	P14902
D	—	protein	369	—	P14902

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains A, B, C, D
NA · Sodium ion · metal · chains A
PO4 · Phosphate ion · ion · 3 copies · chains B, C
CL · Chloride ion · ion · chains C
GOL · Glycerol · additive · 33 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7NGE · Crystal structure of L-Trp/Indoleamine 2,3-dioxygenagse 1 (hIDO1) complex with the… · the same entry in another collection · chain C against C, TM-score 1.00
P14902 · AlphaFold monomer V2.0 prediction for indoleamine 2,3-dioxygenase 1 (P14902) · a predicted model of the same protein · chain D against A, TM-score 0.98

Analyse

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Every structure of UniProt P14902
Elsewhere: RCSB PDB 7NGE · PDBe 7NGE · UniProt P14902

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