Research workbench
Glutathione-S-transferase glig mutant K127G
Analyse Glutathione-S-transferase glig mutant K127G in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NCT
- Type
- protein
- Length
- 1,421 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione S-transferase glig
- UniProt
- B0Y813
- Pockets
- 18 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E | Glutathione S-transferase glig | protein | 237 | 51% helix, 9% strand | B0Y813 |
| C | Glutathione S-transferase glig | protein | 236 | 50% helix, 9% strand | B0Y813 |
| D | Glutathione S-transferase glig | protein | 238 | 50% helix, 9% strand | B0Y813 |
| F | Glutathione S-transferase glig | protein | 236 | 50% helix, 9% strand | B0Y813 |
Pockets
18 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 526 | 0.75 | 0.83 | 56 | empty |
| 2 | 728 | 0.75 | 0.80 | 60 | empty |
| 3 | 535 | 0.73 | 0.81 | 48 | empty |
| 4 | 502 | 0.73 | 0.82 | 43 | empty |
| 5 | 508 | 0.72 | 0.81 | 47 | empty |
Interfaces
8 interfaces between chains.
- A–D · 2209 Ų buried · 37 hydrogen bonds · protein-protein
- B–F · 2193 Ų buried · 45 hydrogen bonds · protein-protein
- A–C · 598 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 516 Ų buried · 12 hydrogen bonds · protein-protein
- E–F · 488 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7NCT · Glutathione-S-transferase GliG mutant K127G · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B0Y813
- Elsewhere: RCSB PDB 7NCT · PDBe 7NCT · UniProt B0Y813
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.