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Crystal structure of H2DB in complex with HSF2 melanoma neoantigen
Analyse Crystal structure of H2DB in complex with HSF2 melanoma neoantigen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7N9J
- Type
- protein
- Length
- 385 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- H-2 class I histocompatibility antigen, D-B alpha chain; Heat shock factor protein 2…
- UniProt
- P01899, P61769
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | H-2 class I histocompatibility antigen, D-B alpha chain | protein | 276 | 28% helix, 40% strand | P01899 |
| C | Heat shock factor protein 2 | protein | 9 | 0% helix, 0% strand | — |
| B | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 664 | 0.69 | 0.77 | 65 | empty |
| 2 | 81 | 0.39 | 0.78 | 16 | empty |
| 3 | 54 | 0.28 | 0.75 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1355 Ų buried · 28 hydrogen bonds · protein-protein
- A–C · 940 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01899
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 7N9J · PDBe 7N9J · UniProt P01899 · UniProt P61769
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