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Crystal structure of the orphan nuclear receptor lrh-1

Analyse Crystal structure of the orphan nuclear receptor lrh-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PK5
Type: protein
Length: 478 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Orphan nuclear receptor NR5A2
UniProt: P45448
Pockets: 7 · best druggability 0.86

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Orphan nuclear receptor NR5A2	protein	242	70% helix, 2% strand	P45448
B	Orphan nuclear receptor NR5A2	protein	236	72% helix, 1% strand	P45448

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	340	0.86	0.96	30	empty
2	491	0.84	0.90	44	empty
3	448	0.74	0.83	57	empty
4	140	0.69	0.89	23	empty
5	119	0.41	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 377 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1PK5 · Crystal structure of the orphan nuclear receptor LRH-1 · the same entry in another collection · chain A against A, TM-score 1.00
P45448 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 5 group a member 2… · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P45448
Elsewhere: RCSB PDB 1PK5 · PDBe 1PK5 · UniProt P45448

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