Research workbench
Crystal structure of ttnm, a FE(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in streptomyces griseochromogenes at 2 a.
Analyse Crystal structure of ttnm, a FE(II)-alpha-ketoglutarate-dependent hydroxylase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7N7V
- Type
- protein
- Length
- 634 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Predicted hydroxylase
- UniProt
- C6ZCS6
- Ligands
- FE2, CL
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Predicted hydroxylase | protein | 321 | 34% helix, 21% strand | C6ZCS6 |
| B | Predicted hydroxylase | protein | 313 | 35% helix, 21% strand | C6ZCS6 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.57 | 0.79 | 35 | CL |
| 2 | 250 | 0.56 | 0.78 | 34 | FE2, CL |
| 3 | 50 | 0.31 | 0.77 | 14 | empty |
| 4 | 57 | 0.30 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 685 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7N7V · Crystal structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C6ZCS6
- Elsewhere: RCSB PDB 7N7V · PDBe 7N7V · UniProt C6ZCS6
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