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Cryo-EM structure of ATP13A2 D458N/D962N mutant in the E1-apo state, conformation 1
Analyse Cryo-EM structure of ATP13A2 D458N/D962N mutant in the E1-apo state… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7N75
- Type
- protein
- Length
- 1,036 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 3 of polyamine-transporting ATPase 13A2
- EC
- 7.6.2.-
- Pockets
- 16 · best druggability 0.73
Structure
electron microscopy · 1 distinct chain · 45% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 3 of polyamine-transporting ATPase 13A2 (EC 7.6.2.-) | protein | 1036 | 45% helix, 19% strand | — |
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 745 | 0.73 | 0.79 | 97 | empty |
| 2 | 572 | 0.68 | 0.78 | 70 | empty |
| 3 | 422 | 0.65 | 0.78 | 44 | empty |
| 4 | 226 | 0.61 | 0.81 | 25 | empty |
| 5 | 143 | 0.61 | 0.84 | 32 | empty |
Compared structures
- 7N75 · Cryo-EM structure of ATP13A2 D458N/D962N mutant in the E1-apo state, Conformation 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7N75 · PDBe 7N75
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