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Crystal structure of the anti-ebov and sudv monoclonal antibody 1C3 Fab

Analyse Crystal structure of the anti-ebov and sudv monoclonal antibody 1C3 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7N6P
Type: protein
Length: 874 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1C3 Fab heavy chain; 1C3 Fab light chain
Pockets: 8 · best druggability 0.64

Structure

x-ray diffraction · 3 distinct chains · 7% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	1C3 Fab heavy chain	protein	225	9% helix, 48% strand	—
L, B	1C3 Fab light chain	protein	217	6% helix, 53% strand	—
A	1C3 Fab heavy chain	protein	215	6% helix, 48% strand	—

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	471	0.64	0.77	63	empty
2	493	0.61	0.75	45	empty
3	315	0.57	0.77	34	empty
4	64	0.51	0.86	22	empty
5	180	0.49	0.77	33	empty

Interfaces

3 interfaces between chains.

H–L · 2009 Å² buried · 15 hydrogen bonds · protein-protein
A–B · 1759 Å² buried · 14 hydrogen bonds · protein-protein
L–B · 900 Å² buried · 26 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

7N6P · Crystal structure of the anti-EBOV and SUDV monoclonal antibody 1C3 Fab · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7N6P · PDBe 7N6P

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