Research workbench
Complex of recombinant bet V 1 with Fab fragment of REGN5715
Analyse Complex of recombinant bet V 1 with Fab fragment of REGN5715 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7N0V
- Type
- protein
- Length
- 584 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- REGN5715 Fab heavy chain; REGN5715 Fab light chain; Major pollen allergen bet V 1-a
- UniProt
- P15494
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 13% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | REGN5715 Fab heavy chain | protein | 210 | 7% helix, 55% strand | — |
| L | REGN5715 Fab light chain | protein | 215 | 9% helix, 51% strand | — |
| C | Major pollen allergen bet V 1-a | protein | 159 | 26% helix, 41% strand | P15494 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 450 | 0.82 | 0.89 | 49 | empty |
| 2 | 290 | 0.50 | 0.73 | 44 | empty |
| 3 | 198 | 0.46 | 0.74 | 24 | empty |
| 4 | 79 | 0.37 | 0.77 | 18 | empty |
| 5 | 105 | 0.36 | 0.74 | 20 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1788 Ų buried · 12 hydrogen bonds · protein-protein
- H–C · 568 Ų buried · 20 hydrogen bonds · protein-protein
- L–C · 46 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7N0V · Complex of recombinant Bet v 1 with Fab fragment of REGN5715 · the same entry in another collection · chain H against H, TM-score 1.00
- P15494 · AlphaFold monomer V2.0 prediction for major pollen allergen bet V 1-a (P15494) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15494
- Elsewhere: RCSB PDB 7N0V · PDBe 7N0V · UniProt P15494
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.