Research workbench
Crystal structure of HPV L1-directed E7M03 Fab
Analyse Crystal structure of HPV L1-directed E7M03 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MX8
- Type
- protein
- Length
- 438 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E7M03 Fab heavy chain; E7M03 Fab light chain
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | E7M03 Fab heavy chain | protein | 222 | 7% helix, 53% strand | — |
| L | E7M03 Fab light chain | protein | 216 | 6% helix, 53% strand | — |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 197 | 0.61 | 0.82 | 31 | empty |
| 2 | 495 | 0.61 | 0.75 | 55 | empty |
| 3 | 73 | 0.53 | 0.86 | 20 | empty |
| 4 | 59 | 0.28 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- H–L · 1997 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7MX8 · Crystal Structure of HPV L1-directed E7M03 Fab · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7MX8 · PDBe 7MX8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.