Research workbench
Paired helical tau filament extracted from gss patient brain tissue | tau filament from gerstmann straussler scheinker disease | phf tau
Analyse Paired helical tau filament extracted from gss patient brain tissue | tau… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MKH
- Type
- protein
- Length
- 750 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform tau-F of microtubule-associated protein tau
- Pockets
- 11 · best druggability 0.67
Structure
electron microscopy · 1 distinct chain · 0% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Isoform tau-F of microtubule-associated protein tau | protein | 75 | 0% helix, 57% strand | — |
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.67 | 0.89 | 29 | empty |
| 2 | 61 | 0.63 | 0.91 | 23 | empty |
| 3 | 60 | 0.62 | 0.91 | 19 | empty |
| 4 | 60 | 0.60 | 0.91 | 23 | empty |
| 5 | 77 | 0.60 | 0.89 | 20 | empty |
Interfaces
30 interfaces between chains.
- A–C · 3214 Ų buried · 88 hydrogen bonds · protein-protein
- C–E · 3214 Ų buried · 87 hydrogen bonds · protein-protein
- E–G · 3213 Ų buried · 87 hydrogen bonds · protein-protein
- G–I · 3212 Ų buried · 88 hydrogen bonds · protein-protein
- B–D · 3201 Ų buried · 86 hydrogen bonds · protein-protein
Compared structures
- 7MKH · Paired helical tau filament extracted from GSS Patient brain tissue | tau filament from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7MKH · PDBe 7MKH
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.