Research workbench
Crystal structure of ATP-dependent protease ATPase subunit hslu in complex with adenosine 5'-diphosphate
Analyse Crystal structure of ATP-dependent protease ATPase subunit hslu in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MHB
- Type
- protein
- Length
- 611 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent protease ATPase subunit hslu
- UniProt
- Q2YQZ4
- Ligands
- ADP, SO4
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent protease ATPase subunit hslu | protein | 306 | 55% helix, 12% strand | Q2YQZ4 |
| B | ATP-dependent protease ATPase subunit hslu | protein | 305 | 55% helix, 12% strand | Q2YQZ4 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 6 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 684 | 0.69 | 0.77 | 73 | ADP, SO4, EDO |
| 2 | 606 | 0.68 | 0.77 | 60 | ADP, SO4, EDO |
| 3 | 84 | 0.43 | 0.80 | 14 | empty |
| 4 | 80 | 0.39 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 263 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7MHB · Crystal structure of ATP-dependent protease ATPase subunit HslU in complex with Adenosine… · the same entry in another collection · chain A against A, TM-score 1.00
- Q2YQZ4 · AlphaFold monomer V2.0 prediction for ATP-dependent protease ATPase subunit hslu (Q2YQZ4) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2YQZ4
- Elsewhere: RCSB PDB 7MHB · PDBe 7MHB · UniProt Q2YQZ4
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