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SARS-cov-2 main protease (mpro) C145A in complex with cleavage site NSP7/8 (P6-P1)

Analyse SARS-cov-2 main protease (mpro) C145A in complex with cleavage site NSP7/8… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7MB7
Type: protein
Length: 308 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase; Asn-arg-ala-thr-leu-gln
EC: 3.4.22.69
UniProt: P0DTD1
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.22.69)	protein	302	25% helix, 29% strand	P0DTD1
B	Asn-arg-ala-thr-leu-gln	protein	6	0% helix, 33% strand	P0DTD1

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.31	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 591 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

7MB7 · SARS-CoV-2 Main Protease (Mpro) C145A in Complex with Cleavage Site Nsp7/8 (P6-P1) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTD1
Elsewhere: RCSB PDB 7MB7 · PDBe 7MB7 · UniProt P0DTD1

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