Research workbench
Yeast actin interacting protein 1 (AIP1), se-met protein, monoclinic crystal form
Analyse Yeast actin interacting protein 1 (AIP1), se-met protein, monoclinic crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1PGU
- Type
- protein
- Length
- 1,214 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin interacting protein 1
- UniProt
- P46680
- Ligands
- ZN
- Pockets
- 14 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Actin interacting protein 1 | protein | 606 | 1% helix, 53% strand | P46680 |
| B | Actin interacting protein 1 | protein | 608 | 0% helix, 53% strand | P46680 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 762 | 0.76 | 0.81 | 63 | empty |
| 2 | 1104 | 0.76 | 0.79 | 74 | empty |
| 3 | 756 | 0.75 | 0.80 | 59 | empty |
| 4 | 409 | 0.74 | 0.84 | 38 | empty |
| 5 | 442 | 0.73 | 0.83 | 40 | empty |
Interfaces
1 interface between chains.
- A–B · 885 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified, 1 disulfide (engineered, disulfide).
Compared structures
- 1PGU · YEAST ACTIN INTERACTING PROTEIN 1 (AIP1), Se-Met PROTEIN, MONOCLINIC CRYSTAL FORM · the same entry in another collection · chain A against A, TM-score 1.00
- P46680 · AlphaFold monomer V2.0 prediction for actin-interacting protein 1 (P46680) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46680
- Elsewhere: RCSB PDB 1PGU · PDBe 1PGU · UniProt P46680
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