Research workbench
Crystal structure of enoyl-CoA hydratase ECHA15 protein from mycolicibacterium paratuberculosis
Analyse Crystal structure of enoyl-CoA hydratase ECHA15 protein from mycolicibacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7M3W
- Type
- protein
- Length
- 800 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Enoyl-CoA hydratase ECHA15
- EC
- 4.2.1.17
- UniProt
- Q73W60
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Enoyl-CoA hydratase ECHA15 (EC 4.2.1.17) | protein | 266 | 54% helix, 16% strand | Q73W60 |
| B, C | Enoyl-CoA hydratase ECHA15 (EC 4.2.1.17) | protein | 267 | 55% helix, 16% strand | Q73W60 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.75 | 0.96 | 30 | empty |
| 2 | 420 | 0.71 | 0.82 | 53 | empty |
| 3 | 214 | 0.69 | 0.86 | 37 | empty |
| 4 | 283 | 0.68 | 0.83 | 42 | empty |
| 5 | 88 | 0.57 | 0.86 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1371 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 1358 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 1323 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7M3W · Crystal Structure of enoyl-CoA hydratase EchA15 protein from Mycolicibacterium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q73W60
- Elsewhere: RCSB PDB 7M3W · PDBe 7M3W · UniProt Q73W60
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