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Methionyl-tRNA synthetase from escherichia COLI complexed with methioninyl adenylate

Analyse Methionyl-tRNA synthetase from escherichia COLI complexed with methioninyl… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PG0
Type: protein
Length: 492 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methionyl-tRNA synthetase
EC: 6.1.1.10
UniProt: P00959
Ligands: MOD
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methionyl-tRNA synthetase (EC 6.1.1.10)	protein	492	55% helix, 14% strand	P00959

Ligands and binding sites

MOD · L-methionyl adenylate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	281	0.59	0.78	32	MOD
2	82	0.36	0.76	15	empty

Compared structures

1PG0 · Methionyl-trna synthetase from escherichia coli complexed with methioninyl adenylate · the same entry in another collection · chain A against A, TM-score 1.00
P00959 · AlphaFold monomer V2.0 prediction for methionine--tRNA ligase (P00959) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00959
Elsewhere: RCSB PDB 1PG0 · PDBe 1PG0 · UniProt P00959

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