Research workbench
Cryo-EM structure of rsv pref bound by fabs 32.4K and 01.4B
Analyse Cryo-EM structure of rsv pref bound by fabs 32.4K and 01.4B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LUC
- Type
- protein
- Length
- 2,754 residues
- Chains
- 15
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0; 01.4B Fab heavy chain; 01.4B Fab light chain; 32.4K Fab heavy…
- UniProt
- C3UPB8
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 5 distinct chains · 17% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Fusion glycoprotein F0 | protein | 449 | 32% helix, 30% strand | C3UPB8 |
| D, F, H | 01.4B Fab heavy chain | protein | 121 | 7% helix, 49% strand | — |
| E, G, I | 01.4B Fab light chain | protein | 112 | 0% helix, 43% strand | — |
| J, L, N | 32.4K Fab heavy chain | protein | 129 | 5% helix, 48% strand | — |
| K, M, O | 32.4K Fab light chain | protein | 107 | 0% helix, 50% strand | — |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 980 | 0.85 | 0.86 | 93 | empty |
| 2 | 1033 | 0.84 | 0.85 | 120 | empty |
| 3 | 927 | 0.77 | 0.80 | 74 | empty |
| 4 | 865 | 0.76 | 0.80 | 67 | empty |
| 5 | 1082 | 0.76 | 0.78 | 77 | empty |
Interfaces
30 interfaces between chains.
- A–B · 2072 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 2059 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 2008 Ų buried · 14 hydrogen bonds · protein-protein
- N–O · 967 Ų buried · 4 hydrogen bonds · protein-protein
- L–M · 957 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 33 disulfide (disulfide).
Compared structures
- 7LUC · Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C3UPB8
- Elsewhere: RCSB PDB 7LUC · PDBe 7LUC · UniProt C3UPB8
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