Research workbench
NSE5-6 complex
Analyse NSE5-6 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LTO
- Type
- protein
- Length
- 605 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural maintenance of chromosome element 5; Ubiquitin-like protein SMT3,DNA…
- UniProt
- Q03718, P40026
- Pockets
- 9 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 49% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-structural maintenance of chromosome element 5 | protein | 367 | 49% helix, 1% strand | Q03718 |
| B | Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera | protein | 238 | 50% helix, 1% strand | P40026 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 786 | 0.80 | 0.84 | 79 | empty |
| 2 | 213 | 0.80 | 0.93 | 27 | empty |
| 3 | 248 | 0.74 | 0.88 | 36 | empty |
| 4 | 176 | 0.66 | 0.86 | 36 | empty |
| 5 | 135 | 0.45 | 0.77 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1889 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 7LTO · Nse5-6 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q03718 · AlphaFold monomer V2.0 prediction for non-structural maintenance of chromosome element 5… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P40026 · AlphaFold monomer V2.0 prediction for DNA repair protein KRE29 (P40026) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03718
- Every structure of UniProt P40026
- Elsewhere: RCSB PDB 7LTO · PDBe 7LTO · UniProt Q03718 · UniProt P40026
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