Research workbench

Nora in complex with FAB36

Analyse Nora in complex with FAB36 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7LO8
Type: protein
Length: 815 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Quinolone resistance protein nora; FAB36 heavy chain; FAB36 light chain
UniProt: Q53459
Pockets: 10 · best druggability 0.84

Structure

electron microscopy · 3 distinct chains · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
Z	Quinolone resistance protein nora	protein	369	78% helix, 0% strand	Q53459
H	FAB36 heavy chain	protein	231	7% helix, 38% strand	—
L	FAB36 light chain	protein	215	4% helix, 40% strand	—

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	261	0.84	0.95	35	empty
2	245	0.66	0.83	52	empty
3	405	0.58	0.75	56	empty
4	102	0.42	0.78	22	empty
5	61	0.41	0.81	14	empty

Interfaces

3 interfaces between chains.

H–L · 2147 Å² buried · 17 hydrogen bonds · protein-protein
Z–H · 1535 Å² buried · 13 hydrogen bonds · protein-protein
Z–L · 977 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

7LO8 · NorA in complex with Fab36 · the same entry in another collection · chain Z against Z, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53459
Elsewhere: RCSB PDB 7LO8 · PDBe 7LO8 · UniProt Q53459

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.