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Circularly permuted BB2-crystallin

Analyse Circularly permuted BB2-crystallin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1BD7
Type: protein
Length: 347 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Circularly permuted BB2-crystallin
UniProt: P62697
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 11% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Circularly permuted BB2-crystallin	protein	176	11% helix, 44% strand	P62697
B	Circularly permuted BB2-crystallin	protein	171	10% helix, 48% strand	P62697

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.55	0.84	19	empty
2	69	0.34	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 1477 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

1BD7 · Circularly permuted BB2-crystallin · the same entry in another collection · chain A against A, TM-score 1.00
P62697 · AlphaFold monomer V2.0 prediction for beta-crystallin B2 (P62697) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62697
Elsewhere: RCSB PDB 1BD7 · PDBe 1BD7 · UniProt P62697

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