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Crystal structure of the nucleic acid binding domain (nab) of NSP3 from SARS-cov-2
Analyse Crystal structure of the nucleic acid binding domain (nab) of NSP3 from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LGO
- Type
- protein
- Length
- 222 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 3
- UniProt
- P0DTD1
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-structural protein 3 | protein | 113 | 21% helix, 23% strand | P0DTD1 |
| B | Non-structural protein 3 | protein | 109 | 19% helix, 25% strand | P0DTD1 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 345 | 0.71 | 0.83 | 46 | empty |
| 2 | 63 | 0.30 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 515 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7LGO · Crystal structure of the nucleic acid binding domain (NAB) of Nsp3 from SARS-CoV-2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 7LGO · PDBe 7LGO · UniProt P0DTD1
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