Research workbench
Crystal structure of the candida albicans kinesin-8 motor domain
Analyse Crystal structure of the candida albicans kinesin-8 motor domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LFF
- Type
- protein
- Length
- 663 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-like protein
- UniProt
- A0A1D8PKA4
- Ligands
- ADP, MG
- Pockets
- 8 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin-like protein | protein | 331 | 31% helix, 27% strand | A0A1D8PKA4 |
| B | Kinesin-like protein | protein | 332 | 30% helix, 27% strand | A0A1D8PKA4 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.56 | 0.84 | 27 | empty |
| 2 | 88 | 0.54 | 0.85 | 26 | empty |
| 3 | 112 | 0.41 | 0.76 | 24 | ADP, MG |
| 4 | 123 | 0.40 | 0.75 | 24 | MG |
| 5 | 89 | 0.36 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1031 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 7LFF · Crystal structure of the Candida albicans kinesin-8 motor domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1D8PKA4
- Elsewhere: RCSB PDB 7LFF · PDBe 7LFF · UniProt A0A1D8PKA4
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