Research workbench
Factor H enhancing human antibody fragment (Fab) to meningococcal factor H binding protein
Analyse Factor H enhancing human antibody fragment (Fab) to meningococcal factor H… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LCV
- Type
- protein
- Length
- 628 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin heavy chain fd fragment; Immunoglobulin kappa light chain; Factor H…
- UniProt
- Q6VRZ6
- Ligands
- CL
- Pockets
- 9 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 4% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Immunoglobulin heavy chain fd fragment | protein | 186 | 5% helix, 46% strand | — |
| B | Immunoglobulin kappa light chain | protein | 215 | 5% helix, 53% strand | — |
| C | Factor H binding protein | protein | 227 | 3% helix, 62% strand | Q6VRZ6 |
Ligands and binding sites
- CL · Chloride ion · ion · 2 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 431 | 0.61 | 0.76 | 50 | empty |
| 2 | 212 | 0.56 | 0.79 | 34 | empty |
| 3 | 51 | 0.50 | 0.88 | 22 | empty |
| 4 | 52 | 0.37 | 0.80 | 15 | empty |
| 5 | 99 | 0.36 | 0.74 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1673 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 650 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 245 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7LCV · Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6VRZ6
- Elsewhere: RCSB PDB 7LCV · PDBe 7LCV · UniProt Q6VRZ6
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