Research workbench
Structure of a ferrichrome importer fhucdb from E. COLI
Analyse Structure of a ferrichrome importer fhucdb from E. COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LB8
- Type
- protein
- Length
- 1,405 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IRON(3+)-hydroxamate import system permease protein fhub; IRON(3+)-hydroxamate-binding…
- EC
- 7.2.2.16
- UniProt
- P06972, P07822, P07821
- Pockets
- 19 · best druggability 0.88
Structure
electron microscopy · 3 distinct chains · 58% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | IRON(3+)-hydroxamate import system permease protein fhub | protein | 630 | 75% helix, 0% strand | P06972 |
| D | IRON(3+)-hydroxamate-binding protein fhud | protein | 265 | 41% helix, 16% strand | P07822 |
| U, C | IRON(3+)-hydroxamate import ATP-binding protein fhuc (EC 7.2.2.16) | protein | 255 | 33% helix, 16% strand | P07821 |
Pockets
19 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1105 | 0.88 | 0.89 | 112 | empty |
| 2 | 1050 | 0.84 | 0.85 | 113 | empty |
| 3 | 384 | 0.79 | 0.88 | 67 | empty |
| 4 | 769 | 0.78 | 0.82 | 93 | empty |
| 5 | 109 | 0.72 | 0.93 | 27 | empty |
Interfaces
4 interfaces between chains.
- B–D · 2644 Ų buried · 22 hydrogen bonds · protein-protein
- U–C · 1169 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 901 Ų buried · 2 hydrogen bonds · protein-protein
- B–U · 899 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7LB8 · Structure of a ferrichrome importer FhuCDB from E. coli · the same entry in another collection · chain U against U, TM-score 1.00
- P06972 · AlphaFold monomer V2.0 prediction for IRON(3+)-hydroxamate import system permease protein… · a predicted model of the same protein · chain B against A, TM-score 0.96
- P07821 · AlphaFold monomer V2.0 prediction for IRON(3+)-hydroxamate import ATP-binding protein… · a predicted model of the same protein · chain U against A, TM-score 0.94
- P07822 · AlphaFold monomer V2.0 prediction for IRON(3+)-hydroxamate-binding protein fhud (P07822) · a predicted model of the same protein · chain D against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06972
- Every structure of UniProt P07822
- Every structure of UniProt P07821
- Elsewhere: RCSB PDB 7LB8 · PDBe 7LB8 · UniProt P06972 · UniProt P07822 · UniProt P07821
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