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The structure of a sensor domain of a histidine kinase (vxra) from vibrio cholerae O1 biovar eltor str. N16961, N239 deletion mutant
Analyse The structure of a sensor domain of a histidine kinase (vxra) from vibrio… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LA6
- Type
- protein
- Length
- 219 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor histidine kinase
- UniProt
- Q9KM24
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor histidine kinase | protein | 219 | 50% helix, 13% strand | Q9KM24 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · 4 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.46 | 0.75 | 22 | empty |
| 2 | 52 | 0.39 | 0.81 | 11 | PG4 |
| 3 | 97 | 0.39 | 0.76 | 16 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7LA6 · THE STRUCTURE OF A SENSOR DOMAIN OF A HISTIDINE KINASE (VxrA) FROM VIBRIO CHOLERAE O1… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KM24
- Elsewhere: RCSB PDB 7LA6 · PDBe 7LA6 · UniProt Q9KM24
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