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Wild-type pseudomonas fluorescens isocyanide hydratase (wt-2) at 274K, REFMAC5-refined

Analyse Wild-type pseudomonas fluorescens isocyanide hydratase (wt-2) at 274K… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7L9S
Type: protein
Length: 456 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isonitrile hydratase inha
EC: 4.2.1.103
UniProt: Q4K977
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isonitrile hydratase inha (EC 4.2.1.103)	protein	226	42% helix, 19% strand	Q4K977
B	Isonitrile hydratase inha (EC 4.2.1.103)	protein	230	42% helix, 20% strand	Q4K977

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	244	0.59	0.80	28	empty
2	248	0.58	0.79	27	empty
3	59	0.32	0.77	16	empty
4	58	0.29	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 2557 Å² buried · 43 hydrogen bonds · protein-protein

Compared structures

7L9S · Wild-type Pseudomonas fluorescens isocyanide hydratase (WT-2) at 274K, Refmac5-refined · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4K977
Elsewhere: RCSB PDB 7L9S · PDBe 7L9S · UniProt Q4K977

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