Research workbench
BG505 SOSIP.V5.2 N241/N289 in complex with the polyclonal Fab pabc-4 from animal RH.33311 (WK26 time point)
Analyse BG505 SOSIP.V5.2 N241/N289 in complex with the polyclonal Fab pabc-4 from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7L8X
- Type
- protein
- Length
- 1,936 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BG505 SOSIP.V5.2 N241/N289 - GP120; BG505 SOSIP.V5.2 N241/N289 - GP41; RH.33311 pabc-4…
- Ligands
- NAG, MAN, BMA
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 8 distinct chains · 24% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BG505 SOSIP.V5.2 N241/N289 - GP120 | protein | 444 | 16% helix, 42% strand | — |
| B | BG505 SOSIP.V5.2 N241/N289 - GP41 | protein | 145 | 70% helix, 6% strand | — |
| C | BG505 SOSIP.V5.2 N241/N289 - GP120 | protein | 439 | 14% helix, 40% strand | — |
| D | BG505 SOSIP.V5.2 N241/N289 - GP41 | protein | 128 | 61% helix, 5% strand | — |
| H | RH.33311 pabc-4 - heavy chain | protein | 116 | 3% helix, 46% strand | — |
| L | RH.33311 pabc-4 - light chain | protein | 99 | 0% helix, 27% strand | — |
| E | BG505 SOSIP.V5.2 N241/N289 - GP120 | protein | 427 | 15% helix, 43% strand | — |
| F | BG505 SOSIP.V5.2 N241/N289 - GP41 | protein | 138 | 64% helix, 5% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 88 copies · chains A, B, C, D, E, F, H
- MAN · alpha-D-mannopyranose · sugar · 11 copies · chains A, L, C, E
- BMA · beta-D-mannopyranose · sugar · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 783 | 0.81 | 0.84 | 79 | empty |
| 2 | 504 | 0.80 | 0.87 | 64 | empty |
| 3 | 485 | 0.80 | 0.87 | 56 | empty |
| 4 | 867 | 0.78 | 0.81 | 89 | empty |
| 5 | 1019 | 0.76 | 0.79 | 114 | empty |
Interfaces
18 interfaces between chains.
- A–B · 2798 Ų buried · 23 hydrogen bonds · protein-protein
- C–D · 2705 Ų buried · 24 hydrogen bonds · protein-protein
- E–F · 2330 Ų buried · 17 hydrogen bonds · protein-protein
- D–F · 1406 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 1262 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 65 glycan, 34 disulfide (N-glycosylation, disulfide).
Compared structures
- 7L8X · BG505 SOSIP.v5.2 N241/N289 in complex with the polyclonal Fab pAbC-4 from animal Rh.33311… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7L8X · PDBe 7L8X
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.