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Crystal structure of the peptidyl-prolyl cis-trans isomerase (ppib) from streptococcus pyogenes.

Analyse Crystal structure of the peptidyl-prolyl cis-trans isomerase (ppib) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7L6Y
Type: protein
Length: 418 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peptidyl-prolyl cis-trans isomerase
EC: 5.2.1.8
UniProt: Q1JI83
Pockets: 8 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)	protein	209	22% helix, 24% strand	Q1JI83

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	295	0.66	0.82	36	empty
2	106	0.34	0.73	19	empty
3	64	0.33	0.77	20	empty
4	80	0.33	0.74	14	empty
5	76	0.32	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 421 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

7L6Y · Crystal Structure of the Peptidyl-Prolyl Cis-Trans Isomerase (PpiB) from Streptococcus… · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt Q1JI83
Elsewhere: RCSB PDB 7L6Y · PDBe 7L6Y · UniProt Q1JI83

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