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Crystal structure of the class D beta-lactamase oxa-935 from pseudomonas aeruginosa, monoclinic crystal form

Analyse Crystal structure of the class D beta-lactamase oxa-935 from pseudomonas… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7L5V
Type: protein
Length: 492 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase
Pockets: 7 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-lactamase	protein	246	38% helix, 23% strand	—
B	Beta-lactamase	protein	246	38% helix, 23% strand	—

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.70	0.91	32	empty
2	82	0.68	0.93	21	empty
3	436	0.65	0.78	66	empty
4	261	0.57	0.78	41	empty
5	76	0.47	0.82	18	empty

Interfaces

1 interface between chains.

A–B · 1398 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

7L5V · Crystal Structure of the Class D Beta-lactamase OXA-935 from Pseudomonas aeruginosa… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7L5V · PDBe 7L5V

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