Research workbench

Outer dynein arm core subcomplex from C. reinhardtii

Analyse Outer dynein arm core subcomplex from C. reinhardtii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KZN
Type: protein
Length: 4,388 residues
Chains: 19
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heavy chain alpha; Flagellar outer dynein arm heavy chain beta; Dynein gamma chain…
UniProt: A0A2K3DV97, A8J1M5, Q39575, Q39578, P27766, O04355, Q39584, Q39579, Q9SWQ6, A8IY95, Q39580, Q2VIY5, A8J5C4, Q7Y0H2
Pockets: 20 · best druggability 0.88

Structure

electron microscopy · 16 distinct chains · 47% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heavy chain alpha	protein	315	2% helix, 36% strand	A0A2K3DV97
B	Flagellar outer dynein arm heavy chain beta	protein	683	75% helix, 3% strand	A8J1M5
C	Dynein gamma chain, flagellar outer arm	protein	965	68% helix, 1% strand	Q39575
D	Dynein, 78 kda intermediate chain, flagellar outer arm	protein	456	14% helix, 27% strand	Q39578
E	Dynein, 70 kda intermediate chain, flagellar outer arm	protein	474	15% helix, 16% strand	P27766
F	Flagellar outer dynein arm light chain 2	protein	100	30% helix, 30% strand	O04355
G	Dynein 18 kda light chain, flagellar outer arm	protein	138	55% helix, 1% strand	Q39584
H	Dynein 11 kda light chain, flagellar outer arm	protein	91	35% helix, 18% strand	Q39579
I	Dynein light chain roadblock LC7A	protein	103	37% helix, 17% strand	Q9SWQ6
J	Dynein light chain roadblock LC7B	protein	94	30% helix, 27% strand	A8IY95
K, L, M, N	Dynein 8 kda light chain, flagellar outer arm	protein	82	35% helix, 37% strand	Q39580
O	Dynein light chain 9	protein	97	33% helix, 31% strand	Q2VIY5
P	Dynein light chain 10	protein	98	39% helix, 33% strand	A8J5C4
X	DC1	protein	121	93% helix, 0% strand	—
Y	DC2	protein	168	81% helix, 0% strand	—
Z	Outer dynein arm-docking complex protein DC3	protein	157	48% helix, 3% strand	Q7Y0H2

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	975	0.88	0.90	116	empty
2	794	0.83	0.86	102	empty
3	1023	0.82	0.83	80	empty
4	1138	0.79	0.80	80	empty
5	1006	0.78	0.80	115	empty

Interfaces

41 interfaces between chains.

B–E · 2087 Å² buried · 25 hydrogen bonds · protein-protein
B–C · 1921 Å² buried · 8 hydrogen bonds · protein-protein
D–E · 1527 Å² buried · 8 hydrogen bonds · protein-protein
E–I · 1505 Å² buried · 12 hydrogen bonds · protein-protein
D–J · 1439 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

7KZN · Outer dynein arm core subcomplex from C. reinhardtii · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A2K3DV97
Every structure of UniProt A8J1M5
Every structure of UniProt Q39575
Every structure of UniProt Q39578
Every structure of UniProt P27766
Every structure of UniProt O04355
Every structure of UniProt Q39584
Every structure of UniProt Q39579
Every structure of UniProt Q9SWQ6
Every structure of UniProt A8IY95
Every structure of UniProt Q39580
Every structure of UniProt Q2VIY5
Every structure of UniProt A8J5C4
Every structure of UniProt Q7Y0H2
Elsewhere: RCSB PDB 7KZN · PDBe 7KZN · UniProt A0A2K3DV97 · UniProt A8J1M5 · UniProt Q39575 · UniProt Q39578 · UniProt P27766 · UniProt O04355 · UniProt Q39584 · UniProt Q39579 · UniProt Q9SWQ6 · UniProt A8IY95 · UniProt Q39580 · UniProt Q2VIY5 · UniProt A8J5C4 · UniProt Q7Y0H2

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