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Anti-cchfv adi-36121 Fab

Analyse Anti-cchfv adi-36121 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KX4
Type: protein
Length: 856 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adi-36121 Fab light chain; Adi-36121 Fab heavy chain
Pockets: 12 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Adi-36121 Fab light chain	protein	213	6% helix, 52% strand	—
B, D	Adi-36121 Fab heavy chain	protein	215	7% helix, 50% strand	—

Pockets

12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	461	0.63	0.76	61	empty
2	416	0.62	0.77	68	empty
3	312	0.52	0.74	33	empty
4	113	0.50	0.81	24	empty
5	210	0.48	0.75	35	empty

Interfaces

3 interfaces between chains.

A–D · 1924 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 1886 Å² buried · 17 hydrogen bonds · protein-protein
A–C · 914 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

7KX4 · Anti-CCHFV ADI-36121 Fab · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7KX4 · PDBe 7KX4

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