Research workbench
Structure of hsting in complex with novel carbocyclic pyrimidine cdn 1
Analyse Structure of hsting in complex with novel carbocyclic pyrimidine cdn 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KVX
- Type
- protein
- Length
- 181 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stimulator of interferon genes protein
- UniProt
- A0A2R3XZB7
- Ligands
- X5J
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Stimulator of interferon genes protein | protein | 181 | 41% helix, 25% strand | A0A2R3XZB7 |
Ligands and binding sites
- X5J · (2r,5r,7r,8r,10r,12ar,14r,15as,16r)-7-(2-amino-6-oxo-1, 6-dihydro-9H-purin-9-yl)-16-hydroxy-14-[(pyrimidin-4-yl)amino]-2,10-disulfanyldecahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2, 10]pentaoxadiphosphacyclotetradecine-2,10-dione · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.43 | 0.75 | 25 | X5J |
| 2 | 50 | 0.25 | 0.73 | 15 | empty |
Compared structures
- 7KVX · Structure of hSTING in complex with novel carbocyclic pyrimidine CDN 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2R3XZB7
- Elsewhere: RCSB PDB 7KVX · PDBe 7KVX · UniProt A0A2R3XZB7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.