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Cryo-EM structure of mal de rio cuarto virus P9-1 viroplasm protein (dodecamer)

Analyse Cryo-EM structure of mal de rio cuarto virus P9-1 viroplasm protein (dodecamer) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7KVD
Type
protein
Length
3,192 residues
Chains
12
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
P9-1
UniProt
D9U542
Pockets
20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 34% helix, 16% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, B, C, D, E, F, G, H, I, J, K, LP9-1protein26634% helix, 16% strandD9U542

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
111060.850.86170empty
26400.830.87113empty
310190.830.84149empty
410040.830.83143empty
57210.820.86109empty

Interfaces

24 interfaces between chains.

  • F–G · 1411 Ų buried · 10 hydrogen bonds · protein-protein
  • B–C · 1409 Ų buried · 10 hydrogen bonds · protein-protein
  • J–K · 1406 Ų buried · 10 hydrogen bonds · protein-protein
  • H–I · 1403 Ų buried · 10 hydrogen bonds · protein-protein
  • D–E · 1399 Ų buried · 10 hydrogen bonds · protein-protein

Compared structures

  • 7KVD · Cryo-EM structure of Mal de Rio Cuarto virus P9-1 viroplasm protein (dodecamer) · the same entry in another collection · chain A against A, TM-score 1.00

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