Research workbench

Crystal structure of the wd-repeat domain of human KIF21A

Analyse Crystal structure of the wd-repeat domain of human KIF21A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KLJ
Type: protein
Length: 639 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform 2 of kinesin-like protein KIF21A
UniProt: Q7Z4S6
Ligands: UNX
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isoform 2 of kinesin-like protein KIF21A	protein	324	0% helix, 54% strand	Q7Z4S6
B	Isoform 2 of kinesin-like protein KIF21A	protein	315	0% helix, 55% strand	Q7Z4S6

Ligands and binding sites

UNX · Unknown atom or ion · ion · 5 copies · chains A, B
EDO · 1,2-ethanediol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1173	0.83	0.84	94	UNX
2	714	0.74	0.79	57	UNX
3	81	0.38	0.77	19	empty

Interfaces

1 interface between chains.

A–B · 586 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7KLJ · Crystal structure of the WD-repeat domain of human KIF21A · the same entry in another collection · chain A against A, TM-score 1.00
Q7Z4S6 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF21A (Q7Z4S6) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7Z4S6
Elsewhere: RCSB PDB 7KLJ · PDBe 7KLJ · UniProt Q7Z4S6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.