Research workbench
Helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase
Analyse Helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KL7
- Type
- protein
- Length
- 301 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosyltransferase
- EC
- 2.4.-.-
- UniProt
- A0A2L2I2A6
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoribosyltransferase (EC 2.4.-.-) | protein | 154 | 34% helix, 32% strand | A0A2L2I2A6 |
| B | Phosphoribosyltransferase (EC 2.4.-.-) | protein | 147 | 36% helix, 28% strand | A0A2L2I2A6 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 222 | 0.52 | 0.76 | 25 | SO4 |
| 2 | 80 | 0.49 | 0.83 | 20 | empty |
| 3 | 192 | 0.46 | 0.75 | 27 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1790 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7KL7 · Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2L2I2A6
- Elsewhere: RCSB PDB 7KL7 · PDBe 7KL7 · UniProt A0A2L2I2A6
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