Research workbench
Helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase
Analyse Helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KL6
- Type
- protein
- Length
- 295 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosyltransferase
- EC
- 2.4.-.-
- UniProt
- A0A2L2I2A6
- Ligands
- WG7, SO4
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoribosyltransferase (EC 2.4.-.-) | protein | 147 | 35% helix, 32% strand | A0A2L2I2A6 |
| B | Phosphoribosyltransferase (EC 2.4.-.-) | protein | 148 | 36% helix, 29% strand | A0A2L2I2A6 |
Ligands and binding sites
- WG7 · (3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl)phosphonic acid · ligand · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 248 | 0.53 | 0.76 | 31 | WG7, SO4 |
| 2 | 214 | 0.49 | 0.75 | 32 | SO4 |
| 3 | 70 | 0.44 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1772 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7KL6 · Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2L2I2A6
- Elsewhere: RCSB PDB 7KL6 · PDBe 7KL6 · UniProt A0A2L2I2A6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.