Research workbench
Crystal structure of PLEKHA7 pH domain biding inositol-tetraphosphate
Analyse Crystal structure of PLEKHA7 pH domain biding inositol-tetraphosphate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KJZ
- Type
- protein
- Length
- 202 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pleckstrin homology domain-containing family a member 7
- UniProt
- Q6IQ23
- Ligands
- 4IP
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pleckstrin homology domain-containing family a member 7 | protein | 102 | 17% helix, 44% strand | Q6IQ23 |
| B | Pleckstrin homology domain-containing family a member 7 | protein | 100 | 18% helix, 43% strand | Q6IQ23 |
Ligands and binding sites
- 4IP · Inositol-(1,3,4,5)-tetrakisphosphate · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.71 | 0.86 | 30 | 4IP |
Interfaces
1 interface between chains.
- A–B · 383 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7KJZ · crystal structure of PLEKHA7 PH domain biding inositol-tetraphosphate · the same entry in another collection · chain A against A, TM-score 1.00
- Q6IQ23 · AlphaFold monomer V2.0 prediction for pleckstrin homology domain- containing family a… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6IQ23
- Elsewhere: RCSB PDB 7KJZ · PDBe 7KJZ · UniProt Q6IQ23
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.