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The 2.5 ångströms structure of pokeweed antiviral protein

Analyse The 2.5 ångströms structure of pokeweed antiviral protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PAF
Type: protein
Length: 524 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pokeweed antiviral protein
UniProt: P10297
Pockets: 1 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Pokeweed antiviral protein	protein	262	38% helix, 24% strand	P10297

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	983	0.79	0.80	96	empty

Interfaces

1 interface between chains.

A–B · 520 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1PAF · The 2.5 ångströms structure of pokeweed antiviral protein · the same entry in another collection · chain B against B, TM-score 1.00
P10297 · AlphaFold monomer V2.0 prediction for antiviral protein I (P10297) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10297
Elsewhere: RCSB PDB 1PAF · PDBe 1PAF · UniProt P10297

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