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Plasmodium falciparum protein PF12P

Analyse Plasmodium falciparum protein PF12P in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KJ7
Type: protein
Length: 525 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Surface protein P12P
UniProt: C6KSX1
Pockets: 3 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Surface protein P12P	protein	266	4% helix, 48% strand	C6KSX1
A	Surface protein P12P	protein	259	7% helix, 50% strand	C6KSX1

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	199	0.54	0.78	29	empty
2	169	0.52	0.79	28	empty
3	67	0.32	0.75	14	empty

Interfaces

1 interface between chains.

B–A · 577 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

7KJ7 · Plasmodium falciparum protein Pf12p · the same entry in another collection · chain B against B, TM-score 1.00
C6KSX1 · AlphaFold monomer V2.0 prediction for surface protein P12P (C6KSX1) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C6KSX1
Elsewhere: RCSB PDB 7KJ7 · PDBe 7KJ7 · UniProt C6KSX1

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