Research workbench
SARS-cov-2 spike glycoprotein with two ACE2 bound
Analyse SARS-cov-2 spike glycoprotein with two ACE2 bound in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KJ3
- Type
- protein
- Length
- 4,109 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spike glycoprotein; Angiotensin-converting enzyme 2
- EC
- 3.4.17.23, 3.4.17.-
- UniProt
- P0DTC2, Q9BYF1
- Ligands
- NAG
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 3 distinct chains · 32% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Spike glycoprotein | protein | 981 | 24% helix, 31% strand | P0DTC2 |
| C | Spike glycoprotein | protein | 961 | 24% helix, 34% strand | P0DTC2 |
| D, E | Angiotensin-converting enzyme 2 (EC 3.4.17.23, 3.4.17.-) | protein | 593 | 60% helix, 4% strand | Q9BYF1 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 80 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 432 | 0.84 | 0.92 | 69 | empty |
| 2 | 579 | 0.83 | 0.88 | 74 | empty |
| 3 | 651 | 0.81 | 0.86 | 86 | empty |
| 4 | 384 | 0.80 | 0.89 | 47 | empty |
| 5 | 578 | 0.76 | 0.83 | 49 | empty |
Interfaces
5 interfaces between chains.
- A–C · 4945 Ų buried · 50 hydrogen bonds · protein-protein
- B–C · 4520 Ų buried · 39 hydrogen bonds · protein-protein
- A–B · 4513 Ų buried · 39 hydrogen bonds · protein-protein
- A–E · 1079 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 997 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 58 glycan, 38 disulfide (N-glycosylation, disulfide).
Compared structures
- 7KJ3 · SARS-CoV-2 Spike Glycoprotein with two ACE2 Bound · the same entry in another collection · chain A against A, TM-score 1.00
- 3SCJ · Crystal structure of spike protein receptor-binding domain from a predicted SARS… · a predicted model of the same protein · chain D against A, TM-score 0.99
- 3SCJ · Crystal structure of spike protein receptor-binding domain from a predicted SARS… · a predicted model of the same protein · chain D against A, TM-score 0.99
- 3SCI · Crystal structure of spike protein receptor-binding domain from a predicted SARS… · a predicted model of the same protein · chain D against A, TM-score 0.99
- 3SCI · Crystal structure of spike protein receptor-binding domain from a predicted SARS… · a predicted model of the same protein · chain D against A, TM-score 0.99
- 3SCK · Crystal structure of spike protein receptor-binding domain from a predicted SARS… · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTC2
- Every structure of UniProt Q9BYF1
- Elsewhere: RCSB PDB 7KJ3 · PDBe 7KJ3 · UniProt P0DTC2 · UniProt Q9BYF1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.