Research workbench

Partial CAS6-rt-CAS1--CAS2 complex

Analyse Partial CAS6-rt-CAS1--CAS2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KFT
Type: protein
Length: 1,427 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CAS2; CAS6-rt-CAS1
Pockets: 20 · best druggability 0.78

Structure

electron microscopy · 5 distinct chains · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	CAS2	protein	96	34% helix, 25% strand	—
A	CAS2	protein	90	33% helix, 27% strand	—
D	CAS6-rt-CAS1	protein	332	47% helix, 16% strand	—
C	CAS6-rt-CAS1	protein	568	40% helix, 17% strand	—
E	CAS6-rt-CAS1	protein	341	43% helix, 15% strand	—

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	316	0.78	0.89	59	empty
2	1191	0.74	0.77	134	empty
3	526	0.69	0.79	46	empty
4	224	0.59	0.80	31	empty
5	320	0.59	0.77	49	empty

Interfaces

6 interfaces between chains.

D–E · 1648 Å² buried · 9 hydrogen bonds · protein-protein
B–A · 1579 Å² buried · 26 hydrogen bonds · protein-protein
B–E · 1199 Å² buried · 13 hydrogen bonds · protein-protein
D–C · 1127 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 334 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

7KFT · Partial Cas6-RT-Cas1--Cas2 complex · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7KFT · PDBe 7KFT

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