Research workbench
Cryo-electron microscopy structure of the heavy metal efflux pump cusa in a heterogeneous 2 open and 1 closed protomer conformation
Analyse Cryo-electron microscopy structure of the heavy metal efflux pump cusa in a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KF8
- Type
- protein
- Length
- 3,055 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cation efflux system protein cusa
- UniProt
- P38054
- Ligands
- CU1
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 52% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cation efflux system protein cusa | protein | 1025 | 52% helix, 17% strand | P38054 |
| B, C | Cation efflux system protein cusa | protein | 1015 | 52% helix, 17% strand | P38054 |
Ligands and binding sites
- CU1 · Copper (I) ion · metal · 2 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1082 | 0.84 | 0.85 | 92 | empty |
| 2 | 1028 | 0.83 | 0.84 | 94 | empty |
| 3 | 865 | 0.83 | 0.85 | 93 | empty |
| 4 | 873 | 0.80 | 0.83 | 102 | empty |
| 5 | 699 | 0.77 | 0.82 | 73 | empty |
Interfaces
3 interfaces between chains.
- B–C · 3304 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 3003 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 2913 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 7KF8 · Cryo-electron microscopy structure of the heavy metal efflux pump CusA in a heterogeneous… · the same entry in another collection · chain A against A, TM-score 1.00
- P38054 · AlphaFold monomer V2.0 prediction for cation efflux system protein cusa (P38054) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38054
- Elsewhere: RCSB PDB 7KF8 · PDBe 7KF8 · UniProt P38054
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.