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The crystal structure of the translation initiation factor EIF4E5 from leishmania major

Analyse The crystal structure of the translation initiation factor EIF4E5 from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KCJ
Type: protein
Length: 360 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 4E type 5
UniProt: Q4Q217
Pockets: 6 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 4E type 5	protein	184	39% helix, 29% strand	Q4Q217
B	Eukaryotic translation initiation factor 4E type 5	protein	176	37% helix, 31% strand	Q4Q217

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.52	0.83	16	empty
2	104	0.48	0.80	16	empty
3	96	0.47	0.80	14	empty
4	114	0.41	0.76	26	empty
5	75	0.32	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 1115 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

7KCJ · The crystal structure of the translation initiation factor EIF4E5 from Leishmania major · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4Q217
Elsewhere: RCSB PDB 7KCJ · PDBe 7KCJ · UniProt Q4Q217

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